According to the researchers of University College of London, sertraline first tackles the anxiety and then after few weeks starts working against depression. Sertraline is a common antidepressant which doctors usually prescribe to their patients.
As per the analysts, sertraline is effective is only for those who take under the prescription of a doctor.
Sertraline also called serotonin reuptake inhibitor (SSRI) initiates the whole mechanism by secreting serotonin. Serotonin is a chemical hormone which sparks happiness.
Some common manifestations of depression include mood swings, unhappiness, and lack of concentration.
Researchers state that sertraline only started to show its little effect after 12 weeks and not before it. However, they observed sertraline reduced anxiety within 6 weeks of the uptake and improved the quality of life.
This recent research appears in the journal The Lancet Psychiatry (19th September 2019) and holds the position of a placebo-controlled study.
The increasing trend of antidepressants in 2019
In the United States, as in the U.K., antidepressants are among the most widely recognized physician recommended medications, and their utilization has risen considerably decades before.
According to the American Psychological Association, women are more likely to take antidepressants than men. The statistics for women to men is 16.5% to 8.6%.
During 1999-2002, 7.7% of individuals of and above 12 years old consumed an antidepressant in a month before. This figure rose to 12.7% during 2011-2014.
Specialists endorse antidepressants for depression as well as for different conditions, for example, anxiety.
Researchers for their study selected 653 individuals aged 18-74 years. The individuals encountered only a little or moderate depressive symptoms in their last 2 months.
The enlistment occurred at 179 general professionals (GP) focuses on four urban communities in England, U.K.
The researchers mention that, in this study, all of them including the patients were not sure if antidepressants would bring any benefit to them or not? They say that there is no clear evidence which supports the notion about sertraline imposing more side effects to one than placebo.
Most past preliminaries of antidepressants have occurred in particular mental health settings. They have also never included those individuals, who do not show any signs of depression.
There are a number of significant studies which ended decades before the use of antidepressants was progressively restricted. The reason for the preliminaries was to gain administrative approval.
Researchers suggest the members of the new investigation better speak to the individuals who are accepting antidepressant prescriptions currently.
The need for future examinations
Remarks from specialists who were not associated with the research hold great importance in the study.
Fellow Goodwin, a teacher of psychiatry at the University of Oxford in the U.K., appreciate the work for not adding fuel to the fire but explaining the actual use of antidepressants.
Goodwin and other researchers additionally prescribes that further investigations should also occur to inspect more about the extended use of antidepressant treatment and the challenges one would encounter during the withdrawal.
Dr. Paul Keedwell, an advisor therapist at Cardiff University in the U.K., talks about the limitations of the study. He says, researchers observed antidepressants as less effective in the first few weeks because of a smaller cohort in the study.
According to the researchers, up to this date, this is the largest antidepressant study which did not receive any funding from the pharmaceutical business.
Gemma Lewis says that she and her team is glad about their findings. They have uncovered the true mechanism of antidepressants that is; it first resolves anxiety before the depression.