Omega-3 fatty acid supplements proved no better than placebo at relieving symptoms or signs of dry eye.
National Eye Institute (NEI) funded this study. It is a part of the National Institutes of Health. Dry Eye Assessment and Management (DREAM) Research Group conducted it. It appears in the New England Journal of Medicine.
Dry eye disease occurs when the film that coats the eye no longer maintains a healthy ocular surface, which can lead to discomfort and visual impairment. The condition affects an estimated 14 percent of adults in the United States.
What did the researchers do?
The 27-center trial selected 535 members with something like a six-month history of moderate to extreme dry eye. Among them, 349 individuals took 3 grams day by day of fish-inferred omega-3 fatty acids in five capsules.
Every daily portion contained 2000 mg eicosapentaenoic acid (EPA) and 1000 mg docosahexaenoic acid (DHA). Researchers arbitrarily appointed 186 individuals to the placebo group. They got 5 grams every day of olive oil in indistinguishable capsules.
Blood tests at a year affirmed that 85 percent of individuals in the omega-3 assemble were as yet consistent with the treatment. In the omega-3 group, mean EPA levels quadrupled versus no adjustment in the placebo group.
Mean dimensions of oleic acid, the constituent of olive oil, stayed stable in both treatment gatherings. Essentially, all participants were allowed to keep taking their past meds for dry eye. It included artificial tears and remedy anti-inflammatory eye drops.
Investigators estimated patient-reported side effects as a change from a pattern in the Ocular Surface Disease Index. It is a 100-point scale for surveying dry eye manifestations, with higher qualities speaking to more prominent severity. Following a year, mean indications scores for individuals in the two groups had improved considerably.
What were the results?
There was no noteworthy contrast in the level of side effect improvement between the groups. Indication scores improved by a mean of 13.9 focuses in the omega-3 group. They improved by 12.5 focuses in the placebo group.
A decrease of something like 10 points is sufficiently huge for an individual to see improvement. In general, 61 percent of individuals in the omega-3 group accomplished an improvement in the score. 54 percent in the control group additionally accomplished somewhere around a 10-point improvement in their side effect score. Be that as it may, the distinction between the groups was not factually critical.
What do these findings suggest?
There were no critical contrasts between the groups regarding improvement in indications of dry eye. Clinician assessed the indications of dry eye utilizing state-administered tests. This deliberate the sum and nature of tears and the integrity of the cornea and the conjunctiva. Conjunctiva is the surface tissue that covers the front of the eye.
The discoveries likewise stress the trouble in making a decision about whether a treatment truly helps a specific dry eye quiet. 50% of the people taking placebo reported considerable side effect improvement amid the investigation.