A recent study states that lavender oil protects the liver and kidneys against oxidative stress caused by a toxic chemical like Malathion. The Tunisian researchers conducted the respective study. They tested the vital oil of Spanish lavender (Lavandula stoechas) for its nephroprotective and hepatoprotective activity against Malathion.
Lavender packs volatile compounds possessing a characteristic, pleasant scent. Moreover, it has healing properties and exhibits a significant antioxidant potential.
Malathion is a common insecticide belonging to the organophosphate family. It is often used in both homes and agricultural areas. It has been employed in the public health mosquito control and fruit fly eradication programs.
Although touted to be secure among organophosphates, Malathion remains a highly effective neurotoxin. It intends to kill insects but at the same time causes noteworthy damage to the kidneys and liver of mammalian species.
When Malathion enters our body, it breaks down into malaoxon. Malaoxon is an even more lethal metabolite than the parent chemical. Upon reaching the kidneys and liver, it causes oxidative stress that harms the organs in certain ways.
Antioxidants can avoid such corporal oxidative anxiety. Studies link Lavender to possess such antioxidant properties.
Researchers from the Faculty of Sciences of Tunis (FST) assessed the nephro-protective and heap-protective properties of lavender oil. They set up an animal study employing 96 young male mice. They divided them into eight groups that received diverse treatments.
- The control group. It was assisted as an untreated baseline.
- The Malathion group receiving 200 milligrams per kilogram (mg/kg) of the organophosphate daily.
- Three of the groups were given 10, 30, and 50 mg/kg of lavender essential oil.
- The last three groups were given a mixture of essential oil and Malathion treatment.
The test lasted for 30 days. The animals were monitored for the signs of body weight gain and some other effects.
The mice were sacrificed at the end of the experiment. Their liver and kidneys were harvested for analysis of the morphological and chemical changes induced by the Malathion and lavender essential oil.
The FST researchers informed that Malathion caused antagonistic effects in the mice. These animals did not increase as much body weight from eating the same amounts as untreated mice. At the same time, the livers and kidneys of the malathion-exposed mice upsurge in size. This swelling disturbed the proper flow of blood through these organs.
Moreover, these mice also showed a considerable disturbance in their metabolism which caused damaging effects on their health.
The administration of Malathion to the animals exhibited a corresponding increase in their oxidative stress levels. The concentration of hydrogen peroxide and malondialdehyde were seen to rise rapidly. The activity levels of the antioxidant enzymes glutathione peroxidase and catalase went down. The superoxide dismutase (SOD) enzymes were also affected. Manganese-SOD, copper-SOD, and iron-SOD levels in the kidneys and liver lessened.
The failure of these antioxidant enzymes showed that Malathion exerted damaging oxidative stress against these organs.
However, lavender essential oil was able to back all of the unfavorable effects of Malathion exposure. Mice treated with lavender essential oil were able to increase weight at a normal rate. The relative weight of their liver and kidneys did not rise irrepressibly.
Their metabolism and hemodynamics were reportedly stable. Finally, their kidneys and liver did not face oxidative stress.
Given these results, the researchers stated that the antioxidant assets of lavender oil allowed it to guard the kidneys and liver against oxidative damage.